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Characterization of inhibitory effects of perfluorooctane sulfonate on human hepatic cytochrome P450 isoenzymes: Focusing on CYP2A6

✍ Scribed by Shizuo Narimatsu; Ryoko Nakanishi; Nobumitsu Hanioka; Keita Saito; Hiroyuki Kataoka

Book ID
113518446
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
456 KB
Volume
194
Category
Article
ISSN
0009-2797

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## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to