Characterization of influenza virus variants with different sizes of the non-structural (NS) genes and their potential as a live influenza vaccine in poultry

Evaluation of a virus derived from MDCK

Evaluation of a virus derived from MDCK cells infected persistently with influenza A virus as a potential live-attenuated vaccine candidate in the mouse model

✍ Beixing Liu; Md. Jaber Hossain; Isamu Mori; Yoshinobu Kimura 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 1 views

## Abstract A temperature‐sensitive mutant virus unable to replicate at 38°C was recovered from passage 189 (IVpi‐189) of Madin‐Darby canine kidney cells infected persistently with influenza A. Immunofluorescent staining of the IVpi‐189 virus‐infected cells revealed disrupted transport of the matri