Characterization of in vivo immunoliposome targeting to pulmonary endothelium

✍ Scribed by Kazuo Maruyama; Eric Holmberg; Stephen J. Kennel; Alexander Klibanov; Vladimir P. Torchilin; Leaf Huang

• Book ID: 102918468
• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 900 KB
• Volume: 79
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600791107

✦ Synopsis

0 Two rat monoclonal antibodies, 34A and 2018, which specifically bind to a surface glycoprotein (gpll2) of the pulmonary endothelial cell surface, have been coupled to unilamellar liposomes of -0.25 pm in diameter. The 34A-and 20184iposomes (monoclonal antibodies 273-34A and 41 1-201 8, respectively), but not antibody-free liposomes and liposomes coupled to 14, a nonspecific monoclonal antibody, accumulate efficiently (-30% injected dose