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Characterization of HNK-1 bearing glycoproteins in human peripheral nerve myelin

✍ Scribed by L. H. Van Den Berg; S. A. Sadiq; F. P. Thomas; Norman Latov

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 481 KB
Volume: 25
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490250305

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✦ Synopsis

The HNK-1 carbohydrate epitope, which is shared by several members of the immunoglobulin gene superfamily, is also the target epitope for IgM anti-MAG autoantibodies in patients with demyelinating neuropathy. By Western blot analysis, there are 7 HNK-I immunoreactive glycoproteins in human peripheral nerve myelin, two of which have previously been identified as the myelin associated glycoprotein (MAG) and the Po glycoprotein. In this study, the remaining HNK-1 bearing glycoprotein bands were characterized by immunoblot and NH,-terminal sequence analysis, and were all identified as degradation products or aggregates of the Po glycoprotein. MAG and Po are therefore the only HNK-I bearing glycoproteins in human peripheral nerve myelin.

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