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Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex

โœ Scribed by D. A. Ostrov; C. L. Barnes; L. E. Smith; S. Binns; T. M. Brusko; A. C. Brown; P. S. Quint; S. A. Litherland; D. C. Roopenian; K. A. Iczkowski


Book ID
110892409
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
890 KB
Volume
69
Category
Article
ISSN
0001-2815

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We describe a mutant human cell line (LBL 721.174) that has lost a function required for presentation of intracellular viral antigens with class I molecules of the major histocompatibility complex (MHC), but retains the capacity to present defined epitopes as extracellular peptides. The cell also ha