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Characterization of HER2/neu and topoisomerase IIα status by FISH in locally advanced breast cancer

✍ Scribed by Cristina Corzo Contero; Ignacio Tusquets Trias de Bes; Marta Salido Galeote; Josep Maria Corominas Torres; Berta Laquente Saez; Meritxel Bellet Ezquerra; Xavier Fabregat Mayol; Sergio Serrano Figueras; Francesc Solé Ristol


Book ID
110647285
Publisher
Springer Milan
Year
2004
Tongue
Spanish
Weight
180 KB
Volume
6
Category
Article
ISSN
1699-048X

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Topoisomerase II␣ (TOP2A) is a key enzyme in DNA replication and a molecular target for many important anticancer drugs. TOP2A is amplified or deleted together with amplification of the closely located ERBB2/HER-2/neu oncogene in breast cancer. We characterized the copy number aberrations of TOP2A a