Histamine is an important mediator of immediate hypersensitivity for both animals and humans. The action of histamine on target tissues is believed to be mediated by specific cell surface receptors, especially H1 and H2 receptors for hypersensitivity and inflammatory reactions, which involve stimula
Characterization of functional histamine H1 receptors on a cultured smooth muscle cell line
β Scribed by Masato Mitsuhashi; Donald G. Payan
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 928 KB
- Volume
- 134
- Category
- Article
- ISSN
- 0021-9541
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## Abstract Transition of vascular smooth muscle cells from a contractile/quiescent to a secretory/proliferative phenotype is one of the critical steps in atherosclerosis and is instigated by proβinflammatory cytokines released from macrophages that have infiltrated into the vascular wall. In most