## Abstract Common fragile sites (CFSs) are expressed as chromosome gaps in cells of different species including human and mouse as a result of the inhibition of DNA replication. They may serve as hot spots for DNA breakage in processes such as tumorigenesis and chromosome evolution. Using multicol
Characterization of FRA7B, a human common fragile site mapped at the 7p chromosome terminal region
β Scribed by Nazario Bosco; Franca Pelliccia; Angela Rocchi
- Book ID
- 113513795
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 484 KB
- Volume
- 202
- Category
- Article
- ISSN
- 0165-4608
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Loss of DNA sequences within human chromosomal band 7q31.2 is frequently observed in a number of different solid tumors including breast, prostate, and ovarian cancer. This chromosomal band also contains the common fragile site, FRA7G. Many of the common fragile sites occur within chromosomal region
Chromosomal or allelic losses at 3p14 are common in a variety of human tumors, including those of the lung, breast, kidney, and head and neck. This suggests the existence of a tumor suppressor gene in this band. A promising candidate is the recently cloned FHIT gene, which spans the common fragile s