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Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban

โœ Scribed by Zhang, D.; He, K.; Herbst, J. J.; Kolb, J.; Shou, W.; Wang, L.; Balimane, P. V.; Han, Y.-H.; Gan, J.; Frost, C. E.; Humphreys, W. G.


Book ID
126206849
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2013
Tongue
English
Weight
911 KB
Volume
41
Category
Article
ISSN
0090-9556

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Involvement of influx and efflux transpo
โœ Yukio Kato; Tatsuya Miyazaki; Takashi Kano; Tomoko Sugiura; Yoshiyuki Kubo; Akir ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 256 KB

Gastrointestinal absorption of several beta-blockers is inhibited by citrus juices, although molecular mechanism(s) lying on their small intestinal absorption has not yet been identified. Here, we attempted to demonstrate involvement of both influx and efflux transporters in vivo in gastrointestinal