Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device

Determination ofin vitro permeability of

Determination ofin vitro permeability of drug candidates through a Caco-2 cell monolayer by liquid chromatography/tandem mass spectrometry

✍ Wang, Zhen; Hop, Cornelis E. C. A.; Leung, Kwan H.; Pang, JianMei 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB 👁 1 views

Studying the permeability of compounds across a Caco-2 cell monolayer is an established in vitro model to screen for oral absorption and to evaluate the mechanism of transport. This assay can also be used to evaluate compounds as potential P-glycoprotein substrates and/or inhibitors. The traditional