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Characterization of dihydropyrimidine dehydrogenase in human colorectal tumours

โœ Scribed by McLeod, HL; Sludden, J; Murray, GI; Keenan, RA; Davidson, AI; Park, K; Koruth, M; Cassidy, J

Book ID
109838701
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
966 KB
Volume
77
Category
Article
ISSN
0007-0920

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โœ Elaina S.R. Collie-Duguid; Stephen J. Johnston; Linda Boyce; Nicola Smith; Aaron ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 96 KB

It is essential for actively proliferating cells to increase their rate of DNA synthesis to progress through the cell cycle. This is reflected in the increased uracil usage that is a common feature in solid tumours. Thymidine phosphorylase (TP) anabolises formation of pyrimidine nucleosides availabl