Involvement of cytochrome P450 3A in the
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M. J. Reid; M. W. LamΓ©; D. Morin; D. W. Wilson; H. J. Segall
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Article
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1998
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John Wiley and Sons
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English
β 196 KB
π 1 views
The metabolism and covalent binding of 14 C-monocrotaline in Sprague-Dawley (SD) rat liver microsomes was investigated using the inducers dexamethasone, clotrimazole, pregnenolone-16β£-carbonitrile, and phenobarbital. Monocrotaline is a pyrrolizidine alkaloid (PA) that causes a syndrome in rats that