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Characterization of cyclofructan-based chiral stationary phases by linear free energy relationship

✍ Scribed by Lucie Janečková; Květa Kalíková; Jiří Vozka; Daniel W. Armstrong; Zuzana Bosáková; Eva Tesařová

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
168 KB
Volume
34
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

Cyclofructans (CFs), a new class of chiral selectors, have been recently introduced for application in liquid chromatography and capillary electrophoresis. So far, derivatized CFs have performed interesting separation possibilities for a variety of compounds. The current work is focused on characterization of three different CF‐based chiral stationary phases (CF‐based CSPs), i.e. isopropyl carbamate cyclofructan 6 (IP‐CF6), R‐naphthylethyl carbamate cyclofructan 6 (RN‐CF6) and dimethylphenyl carbamate cyclofructan 7 (DMP‐CF7). The linear free energy relationship (LFER) model was used to reveal the dominant interactions participating in the complex retention mechanism. A set of 44 different test solutes, with known solvation parameters, was used to determine the regression coefficients of the LFER equation under two mobile‐phase compositions in normal separation mode. The LFER results showed that hydrogen bond acidity, hydrophobicity and dipolarity/polarizibility mostly affect the retention and separation process on the CF‐based columns in the studied separation systems.

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