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Characterization of CSOC 882, a novel immortalized ovarian cancer cell line expressing EGFR, HER2, and activated AKT

✍ Scribed by Daniel R. Scoles; James Pavelka; Ilana Cass; Hang Tran; Rae L. Baldwin; Klara Armstrong; Beth Y. Karlan

Book ID: 113960753
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 909 KB
Volume: 104
Category: Article
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2006.07.023

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## Abstract Her‐2/__neu__ (__erb__B‐2) oncogene overexpression is associated with increased tumor progression and metastasis. Fatty acid synthase (FAS), the key lipogenic enzyme responsible for the endogenous synthesis of fatty acids, has been shown to be one of the genes regulated by Her‐2/__neu__