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Characterization of compound-induced hepatotoxicity using gene expression profiling in rat primary hepatocytes

✍ Scribed by Gwo-Jen Day; Lyndsay Brady; Barry Eynon; Mark Fielden; Susan Fujimoto; Kurt Jarnagin; Donald Halbert

Book ID
119378806
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
103 KB
Volume
164
Category
Article
ISSN
0378-4274

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## Abstract The study examined the feasibility of screening for hepatotoxicity by an __in vitro__ gene expression analysis using rat primary hepatocytes and Affymetrix Rat Toxicology U34 arrays. Hepatocytes were exposed for 6 or 24 h to eight drugs, with different mechanisms of hepatotoxicity, at o