Characterization of carbamazepine–Gelucire 50/13 microparticles prepared by a spray-congealing process using ultrasounds
✍ Scribed by Nadia Passerini; Beatrice Perissutti; Mariarosa Moneghini; Dario Voinovich; Beatrice Albertini; Cristina Cavallari; Lorenzo Rodriguez
- Book ID
- 102400800
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 236 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
In this work, the utilization of a spray-congealing technique using a new ultrasonic atomizer to prepare enhanced-release, solvent-free microspheres of carbamazepine (CBZ)±Gelucire 50/13 in different drug-to-polymer ratios was considered. Scanning electron microscopy analysis showed that it was possible to obtain spherically shaped and nonaggregated microparticles; the prevalent particle size was in the range 150±250 mm and the microspheres had a good encapsulation ef®ciency (> 90% in the prevalent size fraction). The in vitro dissolution tests displayed a signi®cant increase of the CBZ dissolution rate from microspheres compared with pure drug and to drug± Gelucire 50/13 physical mixture. Differential scanning calorimetry, hot stage microscopy, X-ray powder diffractometry, and diffuse re¯ectance Fourier transform infrared spectroscopy demonstrated phase stability of the original polymorph of CBZ in all the systems; moreover, no interactions between the drug and Gelucire 50/13 were found. The results of this study suggested that the spray-congealing technique using the ultrasonic atomizer could be considered as a new and interesting method to enhance the dissolution rate of a poorly water-soluble drug as CBZ.