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Characterization of cadmium-binding proteins detected in rat liver by the western blotting technique

✍ Scribed by Aoki, Yasunobu ;Suzuki, Kazuo T.


Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
230 KB
Volume
2
Category
Article
ISSN
0887-2082

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✦ Synopsis


Out of the three cadmium-binding proteins (CD-BPs) in rat liver parenchyma (40K, 29K, and 24K CdBPs), the 40K Cd-BP showed the highest affinity for cadmium (Cd), with a dissociation constant (KD) of 1.2 X 10-'M. This is in between the affinity of human serum albumin KD = 3.8 X 10-5M) and metallothionein (KD = < lo-"). These Cd-BPs may be responsible for hepatic sequestration of cadmium.


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