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Characterization of bombesin/gastrin-releasing peptide receptors in membranes of MKN45 human gastric cancer

✍ Scribed by Halmos, Gabor; Pinski, Jacek; Szoke, Balazs; Schally, Andrew V.

Book ID
123457126
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
720 KB
Volume
85
Category
Article
ISSN
0304-3835

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## Abstract Nude mice bearing xenografts of the gastrin‐responsive human gastric carcinoma MKN45 cell line were treated for 4 to 5 weeks with bombesin/gastrin‐releasing‐peptide(GRP) antagonist (RC‐3095), somatostatin analogues RC‐160 and SMS 201‐995, or the combination of RC‐3095 and RC‐160. Tumor

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BACKGROUND. Bombesin-like peptides can function as autocrine or paracrine growth factors and stimulate the growth of some cancer cells, including human prostate cancer. Three bombesin receptor subtypes, termed gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMBR), and bombesin rece