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Characterization of Benzodiazepine “Combinatorial” Chemical Libraries by On-Line Immunoaffinity Extraction, Coupled Column HPLC−Ion Spray Mass Spectrometry−Tandem Mass Spectrometry

✍ Scribed by Nedved, Michael L.; Habibi-Goudarzi, Sohrab; Ganem, Bruce; Henion, Jack D.


Book ID
126022857
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
542 KB
Volume
68
Category
Article
ISSN
0003-2700

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The cyclization of a linear dynorphin A (Dyn A) analogue to give the lactam derivative cyclo[D-Asp2,DapS]Dyn A(1-13)NH 2 (where Dap = c~,lS-diaminopropionic acid) was studied to evaluate the usefulness of different coupling reagents for side chain to side chain lactam formation. This cyclization pro