Characterization of an established transplantable adenocarcinoma of the gallbladder in Syrian golden hamster

✍ Scribed by Keiji Inoue; Tsutomu Tomioka; Yoshitsugu Tajima; Tomohiro Fukahori; Toshifumi Eto; Tsukasa Tsunoda; Takashi Kanematsu

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 628 KB
• Volume: 56
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930560417

✦ Synopsis

A carcinoma of the gallbladder was transplantable in Syrian golden hamsters. The tumor was induced by subcutaneous injection of N-nitrosobis (2-oxopropyl) amine (BOP) following dissection of the common duct and preparation of a cholecysto-duodenostomy . The histology revealed a poorly differentiated adenocarcinoma. The tumor was inoculated into the cavity of the gallbladder and subcutaneous tissue of the hamster and was transplantable (uptake rate was 100%). This tumor expressed blood grouprelated antigens, including A, H, and P-glycoproteins. To our knowledge, this is the first report of carcinoma of the gallbladder transplantable in a laboratory animal.