Characterization of an anti-Borrelia burgdorferi OspA conformational epitope by limited proteolysis of monoclonal antibody-bound antigen and mass spectrometricpeptide mapping

Involvement of the C-terminal end of the

Involvement of the C-terminal end of the prostrate-specific antigen in a conformational epitope: characterization by proteolytic degradation of monoclonal antibody-bound antigen and mass spectrometry

✍ Sandrine Michel; Eric Forest; Yves Pétillot; Gilbert Deléage; Nathalie Heuzé-Vou 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB

## Abstract Prostate‐specific antigen (PSA), a 237‐amino acid glycoprotein, encoded by the __hKLK3__ gene, is widely used as a serum marker for the diagnosis and management of prostate cancer. We report here the localization of a conformational epitope recognized by the anti‐total PSA monoclonal an