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Characterization of an acute micromegakaryocytic leukaemia: evidence for the pathogenesis of myelofibrosis

โœ Scribed by J. T. Reilly; D. Barnett; G. Dolan; P. Forrest; J. Eastham; A. Smith

Book ID
114713318
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
514 KB
Volume
83
Category
Article
ISSN
0007-1048

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Acute promyelocytic leukaemia (APL) is characterised by chromosomal rearrangements of 17q21, leading to fusion of the gene encoding retinoic acid receptor alpha (RARalpha) to a number of alternative partner genes (X), the most frequent of which are PML (>95%), PLZF (0.8%) and NPM (0.5%). Over the la