✦ LIBER ✦

Characterization of amiodarone metabolites and impurities using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

✍ Scribed by Seung-Woon Myung; Yoon-Jung Chang; Hye-Ki Min; Dong-Hyun Kim; Myungsoo Kim; TaeKyung Kang; Eun-Ah Yoo; Young Taek Sohn; Yong-Hyeon Yim

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 125 KB
Volume: 14
Category: Article
ISSN: 0951-4198
DOI: 10.1002/1097-0231(20001115)14:21<2046::aid-rcm132>3.0.co;2-4

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✦ Synopsis

Using the high performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry (HPLC/APCI-MS/MS) technique, together with established trends from the literature, the structures of metabolites and impurities of amiodarone, an anti-arhythmic drug, have been assigned. By comparing analyses of products of incubation with rat liver microsomes with controls in which glucose 6phosphate dehydrogenase was omitted, metabolites could be distinguished from impurities. Structures for the two proposed metabolites and four impurities are proposed.

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