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Characterization of acetohydroxyacid synthase from Mycobacterium tuberculosis and the identification of its new inhibitor from the screening of a chemical library

✍ Scribed by Kyoung-Jae Choi; Yeon Gyu Yu; Hoh Gyu Hahn; Jung-Do Choi; Moon-Young Yoon


Book ID
116465867
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
297 KB
Volume
579
Category
Article
ISSN
0014-5793

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## Abstract A simple steady‐state kinetic high‐throughput assay was developed for the salicylate synthase MbtI from __Mycobacterium tuberculosis__, which catalyzes the first committed step of mycobactin biosynthesis. The mycobactins are small‐molecule iron chelators produced by __M.β€…tuberculosis__,