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Characterization of a Unique Coenzyme B 6 Radical in the Ascarylose Biosynthetic Pathway

✍ Scribed by Chang, Cheng-Wei T.; Johnson, David A.; Bandarian, Vahe; Zhou, Huiqiang; LoBrutto, Russell; Reed, George H.; Liu, Hung-wen


Book ID
127015288
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
52 KB
Volume
122
Category
Article
ISSN
0002-7863

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The X-ray structure determination at 2.4 A ˚resolution of the putative orsellinic acid C3 O-methyltransferase (CalO1) involved in calicheamicin biosynthesis is reported. Comparison of CalO1 with a homology model of the functionally related calicheamicin orsellinic acid C2 O-methyltransferase (CalO6)