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Characterization of a t(I0; II) (pI3-I4; qI4-2I) in the monoblastic cell line U937

✍ Scribed by Janet Shipley; Sarah Williams; Anne O'Byrne; Lyndal Kearney; Tania Jones; Bryan Young; Martin Dyer; Daniel Catovsky; Denise Sheer; Barry Gusterson

Book ID: 102222054
Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 415 KB
Volume: 13
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870130211

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✦ Synopsis

Previous analysis of the monoblastic cell line U937 has shown that several sublines contain a rearranged chromosome arm I I q.

In order to determine the true nature of the rearrangement, fluorescence in situ hybridization (FISH) was carried out with various combinations of single copy anonymous markers, clones containing genes, a chromosome 10 paint, and an I I centromere specific sequence. The rearrangement was deduced to be a reciprocal translocation between chromosomes I0 and I I described as t( 10; I I )(p I 3-I4;q 14-2 I ). The breakpoint on chromosome I I is telomeric to the /NT2 gene and the pHS I I probe at I I q I 3, and centromeric to the marker D I IS36 localized to I I q I4.3-q22. I and the MLL gene at I I q23. Similar translocations have been reported in various acute leukemias, principally of the monocytic lineage, and also in T-cell precursor acute lymphocytic leukemias. Further characterization of the genetic rearrangements in U937 may lead to the isolation of genes important in leukemogenesis and provide an in vitro system for their study. Genes Chromosom Cancer /3:/38-I42 (1995).

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