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Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins

✍ Scribed by Eliaz, Rom E. ;Kost, Joseph

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
545 KB
Volume
50
Category
Article
ISSN
0021-9304

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✦ Synopsis

Physico-chemical properties of injectable polymeric implant systems, based on the principle that a waterinsoluble polymer dissolved in a biocompatible solvent will precipitate upon contact with water, were studied and utilized to predict the release of proteins from these systems. Polylactide-co-glycolide copolymer (PLGA) and glycofurol were chosen since they both have pharmaceutical precedence. Changes in polymer composition, its weight percent in solution, molecular weight, and protein loading level were assessed to provide formulations with the desired release rates and duration of release.

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