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Characterization of a peripheral-type benzodiazepine-binding site in the mitochondria of Chinese hamster ovary cells

✍ Scribed by J. Riond; N. Vita; G. Le Fur; P. Ferrara

Book ID
115921592
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
649 KB
Volume
245
Category
Article
ISSN
0014-5793

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Subcellular fractionation was performed on human U251 glioblastoma cultures. In all subcellular fractions, the binding of the peripheral benzodiazepine ligand, [3H]PK 11195, correlated with the specific activity of monoamine oxidase (r = 0.95, p less than 0.001) and succinate dehydrogenase (r = 0.93