Characterization of a latent protein encoded by the large internal repeats and the BamHI Y Fragment of the epstein-barr virus (ebv) genome
β Scribed by Marlies Sauter; Harald Boos; Friedrich Hirsch; Nikolaus Mueller-Lantzsch
- Book ID
- 113208970
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 517 KB
- Volume
- 166
- Category
- Article
- ISSN
- 0042-6822
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Two genes encoding the latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) were isolated from a single case of Hodgkin's disease (HD) and were tested for their biological activities. The LMP1 gene from the Reed-Sternberg cells contained point mutations relative to the prototype LMP1 gen
## Abstract Epstein-Barr virus (EBV) is a ubiquitous virus with infections commonly resulting in a latency carrier state. Although the exact role of EBV in cancer pathogenesis remains not entirely clear, it is highly probable that it causes several lymphoid and epithelial malignancies, such as Hodg