We previously reported that DX-8951f, a novel watersoluble camptothecin analog, significantly inhibits the growth of various human and murine tumors in vitro and in vivo. The antitumor effects and topoisomerase I inhibitory activity of DX-8951f are stronger than those of other current camptothecin a
✦ LIBER ✦
Characterization of a Human Small-cell Lung Cancer Cell Line Resistant to a New Water-soluble Camptothecin Derivative, DX-8951f
✍ Scribed by Nomoto, Taisuke ;Nishio, Kazuto ;Ishida, Tomoyuki ;Mori, Masatomo ;Saijo, Nagahiro
- Book ID
- 108581536
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1998
- Tongue
- English
- Weight
- 386 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0910-5050
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## Abstract The epidermal growth factor receptor (EGFR) tyrosine‐kinase inhibitor gefitinib (Iressa®, ZD1839) has shown promising activity preclinically and clinically. Because comparative investigations of drug‐resistant sublines with their parental cells are useful approaches to identifying the m