Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population

✍ Scribed by Sylviane Olschwang; Pierre Laurent-Puig; Anne Vassal; Rémy-J. Salmon; Gilles Thomas

• Book ID: 104661341
• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 207 KB
• Volume: 86
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00201836

✦ Synopsis

We describe a simple method for characterizing a frequent polymorphism (that subsitutes an arginine for a proline) in the coding sequence of the Tp53 gene in patients with colonic cancer and in a control population. We could find no evidence that this polymorphism is associated with a marked predisposition to colorectal cancer.