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Characterization of a CHO cell line resistant to killing by the hypoxic cell cytotoxin SR 4233

โœ Scribed by Amato J. Giaccia; Kim A. Biedermann; Liana M. Tosto; Andrew I. Minchinton; Mary S. Kovacs; J.Martin Brown


Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
447 KB
Volume
22
Category
Article
ISSN
0360-3016

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CHO cell lines that constitutively produce the murine interferon-alpha (IFN-alpha) subspecies alpha 4 and alpha 6 were constructed. The producer cell lines were protected against viral (vesicular stomatitis virus) infection by the IFN species secreted, but were resistant to the growth inhibitory act