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Characterization of a cardiac-selective and developmentally upregulated promoter in tranagenic mice

✍ Scribed by Wolfgang-M. Franz; Gottfried Drem; Werner Rudolph; Kenneth R. Chien; Peter H. Hofschneidor; Reinhard Kandolf


Book ID
115984798
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
98 KB
Volume
24
Category
Article
ISSN
0022-2828

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## Abstract ## Background Systemic administration of non‐viral gene therapy provides better access to tumors than local administration. Development of a promoter that restricts expression of cytotoxic proteins to the tumor vasculature will increase the safety of the system by minimizing expression