Characterization of a 95 kilodalton membrane glycoprotein associated with multi-drug resistance

Cytogenetic and molecular characterizati

Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene, MDR1/P-glycoprotein, in drug-selected cell lines and patients with drug refractory ALL

✍ Turid Knutsen; Lyn A. Mickley; Thomas Ried; Eric D. Green; Stanislas du Manoir; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 835 KB

Drug resistance, both primary and acquired, is a major obstacle to advances in cancer chemotherapy. In vitro, multidrug resistance can be mediated by P-glycoprotein (PGY1), a cell surface phosphoglycoprotein that acts to efflux natural products from cells. PGY1 is encoded by the MDR1 gene located at