Characterization of [3H]clozapine binding sites in rat brain
β Scribed by I. Kusumi; S. Matsubara; Y. Takahashi; T. Ishikane; T. Koyama
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 822 KB
- Volume
- 101
- Category
- Article
- ISSN
- 1435-1463
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Following up h e finQng that the non-imidazole drug clozapine shows a considerable histamine H3 receptor antagonistic activiryl 1.21 , a scrim of analogues and metabolites (clorapinc-N-oxide. and N-desmcthylclozapine) were tested for thcir affinity towards thc H3 receptor using the radiolabelled H,