Characterization and Genomic Mapping of a Novel Leader Peptide Associated with the Human VH4–21 (VH4–34) Gene Segment

Establishment of a novel human B-cell li

Establishment of a novel human B-cell line (OZ) with t(14;18)(q32;q21) and aberrant p53 expression was associated with the homozygous deletions of p15INK4B and p16INK4A genes

✍ M. Nagai; M. Fujita; M. Ohmori; S. Matsubara; M. Taniwaki; S. Horiike; T. Tasaka 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB 👁 1 views

The novel human pre-B cell line OZ was established from a patient with an aggressive form of non-Hodgkin's lymphoma. Karyotypic analysis of both the primary tumour and OZ cells revealed several marker chromosomes, including the t(14;18)(q32;q21) translocation, which involves the Bcl-2 gene, and alte