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Characteristics of calcium accumulation by lymphocytes and alterations in the process induced by phytohemagglutinin

✍ Scribed by Richard B. Whitney; Dr. Robert M. Sutherland

Book ID: 102882355
Publisher: John Wiley and Sons
Year: 1973
Tongue: English
Weight: 874 KB
Volume: 82
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040820103

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✦ Synopsis

Abstract

Calcium uptake by normal human lymphocytes was found to be a saturable process which was competitively inhibited by manganese indicating the existence of a carrier‐mediated mechanism for calcium uptake. Exchange diffusion was not observed, Phytohemagglutinin (PHA) significantly stimulated calcium uptake within minutes after treatment. The increased uptake was attributed to a decreased K~m~ for the proposed membrane carrier rather than to an increased V~max~. Also PHA did not stimulate a normally unused exchange diffusion process, nor did it affect calcium efflux. Uptake by both unstimulated and PHA‐treated lymphocytes was not influenced by magnesium or by cycloheximide or actinomycin D.

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