𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Characteristics of apathy in Parkinson's disease

✍ Scribed by Kathy Dujardin; Pascal Sockeel; David Devos; Marie Delliaux; Pierre Krystkowiak; Alain Destée; Luc Defebvre

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
105 KB
Volume
22
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The objective of this study was to use the Lille Apathy Rating Scale to assess apathy in a large population of Parkinson's disease (PD) patients and identify several different apathy profiles. One hundred fifty‐nine patients with probable PD and 58 healthy controls participated in the study. Apathy was assessed using the Lille Apathy Rating Scale. Motor, cognitive, and depressive symptoms were rated on standardized scales. Data were analyzed using linear regression and multivariate analyses of variance. Thirty‐two percent of the PD patients were classified as apathetic. Apathy was more frequent in patients with dementia. The four apathy dimensions contributed differently to the overall severity of the apathetic condition. Action initiation and intellectual curiosity had a marked influence. Linear regression analysis revealed that the apathy level was mainly determined by cognitive impairment, not associated with the severity of motor symptoms, and only associated with the apathy subcomponent of the Montgomery and Asberg Depression Rating Scale. Apathy is highly prevalent in PD patients. Apathy profiles vary according to the clinical presentation of PD. The high prevalence of apathy in PD suggests the involvement of frontal–subcortical circuits. Although the neurochemical substrate of apathy remains poorly characterized, the strong link between apathy and cognitive impairment observed in several studies suggests the participation of nondopaminergic circuits. © 2007 Movement Disorder Society

📜 SIMILAR VOLUMES

The Apathy Inventory: assessment of apat
The Apathy Inventory: assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive impairment
✍ P. H. Robert; S. Clairet; M. Benoit; J. Koutaich; C. Bertogliati; O. Tible; H. C 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB 👁 2 views

## Abstract ## Objective This study was designed to establish the validity and reliability of the apathy inventory (IA), a rating scale for global assessment of apathy and separate assessment of emotional blunting, lack of initiative, and lack of interest. ## Method Information for the IA can be

Clinical, neuropsychological, and morpho
Clinical, neuropsychological, and morphometric correlates of apathy in Parkinson's disease
✍ Valeria Isella; Paola Melzi; Marco Grimaldi; Simona Iurlaro; Roberto Piolti; Car 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 48 KB

## Abstract Apathy is a salient feature of various neuropsychiatric disorders, from depression to Alzheimer's disease. We formally assess its prevalence in idiopathic Parkinson's disease (PD) together with its clinical, neuropsychological, and morphometric correlates. Thirty patients with PD and 25

The syndromal validity and nosological p
The syndromal validity and nosological position of apathy in Parkinson's disease
✍ Sergio E. Starkstein; Marcelo Merello; Ricardo Jorge; Simone Brockman; David Bru 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 78 KB 👁 1 views

## Abstract Although apathy is among the most frequent behavioral changes in Parkinson's disease (PD), its diagnosis is still problematic, and the overlap with depression and dementia poorly studied. Aim of the study was validate specific criteria to diagnose apathy in PD, and to examine its associ

Apathy may herald cognitive decline and
Apathy may herald cognitive decline and dementia in Parkinson's disease
✍ Kathy Dujardin; Pascal Sockeel; Marie Delliaux; Alain Destée; Luc Defebvre 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB 👁 1 views

## Abstract Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe

Carer burden in apathy and impulse contr
Carer burden in apathy and impulse control disorders in Parkinson's disease
✍ Iracema Leroi; Vijay Harbishettar; Michelle Andrews; Kathryn McDonald; E. Jane B 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB 👁 1 views

## Background The neuropsychiatric complications of Parkinson's disease (PD), which include behaviour disturbances such as apathy and the impulse control disorders (ICDs), may have a significant effect on patients with PD and their carers. The contribution of these behaviour disorders to carer burd

Examination of the Lille Apathy Rating S
Examination of the Lille Apathy Rating Scale in Parkinson disease
✍ Laura B. Zahodne; Shamar Young; Lindsey Kirsch-Darrow; Anne Nisenzon; Hubert H. 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB 👁 1 views

## Abstract Apathy is a unique, multidimensional syndrome commonly encountered in patients with Parkinson disease (PD). Recently, the Lille Apathy Rating Scale (LARS), a semistructured interview yielding a global score, and composite subscores for different domains of apathy (i.e., cognitive, behav