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Characteristics of a novel deep red/infrared fluorescent cell-permeant DNA probe, DRAQ5, in intact human cells analyzed by flow cytometry, confocal and multiphoton microscopy

โœ Scribed by Paul J. Smith; Nicola Blunt; Marie Wiltshire; Terence Hoy; Paul Teesdale-Spittle; Michael R. Craven; James V. Watson; W. Brad Amos; Rachel J. Errington; Laurence H. Patterson


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
391 KB
Volume
40
Category
Article
ISSN
0196-4763

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## Background: The linking of intracellular metabolism of anticancer drugs with cellular response is problematic. We describe a new probe for cellular integrity, based upon a structure which has the additional potential to act as a substrate for cytochrome P450-dependent bioreductive metabolism. DR