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Characteristics and distribution of β thalassemia haplotypes in South China

✍ Scribed by Vivian Chan; T. K. Chan; M. Y. Cheng; N. K. Leung; Y. W. Kan; D. Todd

Publisher
Springer
Year
1986
Tongue
English
Weight
364 KB
Volume
73
Category
Article
ISSN
0340-6717

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✦ Synopsis

Eleven restriction site polymorphisms in the beta-globin gene cluster were determined in 48 Chinese with homozygous beta-thalassemia and their parents. Seven haplotypes were identified as associated with the beta thal chromosome and 25 with the beta A chromosome. The distribution of the various beta thal haplotypes in different regions of South China was mapped and discussed in relation to prenatal diagnosis and migration of the Chinese people.

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