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Characteristics and analysis of normal and leukemic stem cells: current concepts and future directions

✍ Scribed by Brendel, C; Neubauer, A

Book ID: 110054681
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 120 KB
Volume: 14
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2401907

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## Abstract Chronic Myeloid Leukemia (CML), a myeloproliferative disease of stem cell origin, is characterized by the presence of the Philadelphia (Ph) chromosome and the __bcr‐abl__ oncogene. The BCR‐ABL fusion gene product, thought to be causative in CML, has multiple effects on diverse cell func