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Characteristic immunophenotyping artefact seen in patients with anti-mouse immunoglobulin antibodies

✍ Scribed by D. Wilks; N. Byrom; L. Walker; J. Habeshaw; A. Dalgleish

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
139 KB
Volume
11
Category
Article
ISSN
0196-4763

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✦ Synopsis

Abstract

Patients treated with murine monoclonal antibodies develop anti‐mouse immunoglobulin antibodies which can interfere with flow cytometry of lymphocytes, giving rise to high levels of non‐specific staining. This artefact can be avoided by using separated, washed lymphocytes for immunophenotyping.

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