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Characterisation of the inhibition of rab prenylation by phosphonocarboxylates

โœ Scribed by Richard Tavare; Rudi Baron; Adam Taylor; Miguel C. Seabra; Katarzyna M. Blazewska; Charles E. McKenna; Boris A. Kashemirov; Frank H. Ebetino; Michael J. Rogers; Fraser P. Coxon

Book ID
116320532
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
73 KB
Volume
42
Category
Article
ISSN
8756-3282

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Selective inhibition of Rab prenylation
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โœ Anke J. Roelofs; Philippa A. Hulley; Annemieke Meijer; Frank H. Ebetino; R. Grah ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 410 KB

## Abstract Bisphosphonates (BPs) are widely used in the treatment of osteolytic bone disease associated with multiple myeloma, and have been demonstrated to exert antitumor effects both __in vitro__ and __in vivo__. However, the precise molecular mechanisms involved in the direct antitumor effects