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Characterisation of the immune response to type I collagen in scleroderma

✍ Scribed by Kenneth J Warrington, Usha Nair, Laura D Carbone…


Book ID
120707579
Publisher
BioMed Central
Year
2006
Tongue
English
Weight
474 KB
Volume
8
Category
Article
ISSN
1478-6354

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Fibroblasts cultured from affected skin areas of five patients with cutaneous scleroderma were found to produce increased amounts of collagen when compared with nonaffected control cells. Total RNA was isolated from the cultures and analyzed for its level of proal(1)collagen mRNA by hybridization of