Characterisation of products formed by condensations of primary amines with polygodial, and their scope for enantiomer analyses
✍ Scribed by Charles J.W. Brooks; W.John Cole; Philip A. Brindle
- Book ID
- 104144787
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 861 KB
- Volume
- 468
- Category
- Article
- ISSN
- 1873-3778
No coin nor oath required. For personal study only.
✦ Synopsis
The sesquiterpenedial polygodial undergoes smooth reactions with primary amines, under mild conditions, to give stable derivatives (1,3,4_trisubstituted pyrroles) useful for characterisation by gas chromatographyymass spectrometry. Diastereomerit pyrroles formed from chiral amines were in suitable instances separable by gas chromatography. With hydroxy amines it may be advantageous to convert the initial products into 0-trimethylsilyl or O-tert.-butyldimethylsilyl ethers for analysis. All the derivatives studied yielded molecular ions under electron impact, while informative fragmentations also occurred.