Characterisation of genes mapping in a region of 3p21 homozygously deleted in a small cell lung cancer (SCLC) derived cell line
β Scribed by Klaas Kok; Anke van den Berg; Patrick M.J.F. Veldhuis; Miriam Hulsbeek; Anneke Y. van der Veen; Susan L. Naylor; Charles H.C.M. Buys
- Book ID
- 119106349
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 85 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0165-4608
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The recently identified FHIT gene encompasses the FRA3B region and the breakpoint of a constitutive t(3;8) occurring in a family with hereditary renal cell cancer. Occurrence of aberrant transcripts in different types of tumours has led to the suggestion that FHIT might play a critical role in the d
## Abstract Identification of a homozygous deletion in cancer cells provides strong evidence for the location of a tumor suppressor gene (TSG). We analyzed the 2p24 homozygous deletion of a nonβsmallβcell lung cancer (NSCLC) cell line, NCIβH2882, and found that the deletion size was 3.7 Mbp. Since