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Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: Effect of reversing primary and secondary face modifications

✍ Scribed by O’Mahony, A.M.; Doyle, D.; Darcy, R.; Cryan, J.F.; O’Driscoll, C.M.

Book ID
123251972
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
693 KB
Volume
47
Category
Article
ISSN
0928-0987

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Polycationic Amphiphilic Cyclodextrins f
Polycationic Amphiphilic Cyclodextrins for Gene Delivery: Synthesis and Effect of Structural Modifications on Plasmid DNA Complex Stability, Cytotoxicity, and Gene Expression
✍ Alejandro Díaz-Moscoso; Löic Le Gourriérec; Marta Gómez-García; Juan M. Benito; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 592 KB

## Abstract A molecular‐diversity‐oriented approach for the preparation of well‐defined polycationic amphiphilic cyclodextrins (paCDs) as gene‐delivery systems is reported. The synthetic strategy takes advantage of the differential reactivity of primary versus secondary hydroxyl groups on the CD to