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Characterisation of a trisulphide derivative of biosynthetic human growth hormone produced in Escherichia coli

✍ Scribed by Anne Munk JESPERSEN; Thorkild CHRISTENSEN; Niels Kristian KLAUSEN; Per Franklin NIELSEN; Hans Holmegaard SØRENSEN

Book ID
115130999
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
676 KB
Volume
219
Category
Article
ISSN
1432-1327

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Recombinant DNA derived human growth hormone (rhGH), Genotropin, has been expressed in E. coli cells as a pre-hormone, where the heat stable enterotoxin II signal peptide (STII) was linked to hGH to get secretion of the hormone to the periplasmatic space. The pre-hormone was efficiently cleaved duri