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Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient

✍ Scribed by Dr. Graham H. Farrar; Marilynn A. Roff; Tehmina Amin; Jonathan Ball; Alison M. Parrett; Uma Battacharyya; James Booth; Mark H. Wansbrough-Jones; Peter J. Greenaway

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 1000 KB
Volume: 34
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890340207

No coin nor oath required. For personal study only.

✦ Synopsis

Five HIV-1 isolates were obtained sequentially from a single seropositive individual during the later stages of AIDS. Four of these isolates were adapted to grow in a continuous human T-lymphocytic cell line. Comparative biological and biochemical studies of the virus isolates were made using persistently infected cultures or virus derived from these systems respectively. The data obtained clearly shows that viruses with different biological properties can be isolated from the same individual at different times during the course of clinical AIDS.

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