CHARACTERISATION FOR THE MOLECULAR SIGNALLING PATHWAY THROUGH WITH ANDROGEN DEPRIVATION UPREGULATED AKT PHOSPHORYLATION IN LNCAP PROSTATE CANCER CELLS

Inhibition of the Akt, cyclooxygenase-2,

Inhibition of the Akt, cyclooxygenase-2, and matrix metalloproteinase-9 pathways in combination with androgen deprivation therapy: Potential therapeutic approaches for prostate cancer

✍ Hiroshi Miyamoto; Saleh Altuwaijri; Yi Cai; Edward M. Messing; Chawnshang Chang 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB

## Abstract Prostate cancer cells are generally dependent on androgen stimulation mediated by the androgen receptor (AR) for growth and survival, and, therefore, hormonal manipulation, such as castration and/or the use of AR antagonists, results in a regression of the cancer. However, this treatmen